Medical Genomics Japan Variant Database (MGeND) aims to provide the integrated information of genomic variations and clinical characteristics, and to improve clinical interpretation by cross-sectional studies on “Cancer”, “Rare/Intractable disease”, “Infectious Disease”, “Dementia” and “Hearing loss”. This database contains genetic variations and their frequencies with supporting evidence and clinical information that have been provided from research institutions and cooperation hospitals, which were selected for a program for an Integrated Database of Clinical and Genomic Information supported by Japan Agency for Medical Research and Development (AMED). Currently, we are only accepting submissions from research institutions selected for this program.
The curation provided on MGeND is performed by collaborating institutions who submit variants and their curation results. MGeND does not validate the interpretation for a variant or review criteria and evidence for interpretation used by submitters.
In the case of disagreement for interpretations by submitters, MGeND does not determine which is correct, and provides the interpretation provided by each submitter.
Privacy Policy
The information of access users (IP address and query parameters) are saved in log files to control unauthorized access and to improve our service. The statistics of usage collected from these log files are only used for an annual report for AMED and discussion in MGeND. We will not sell, share, or otherwise distribute the information that we will collect to a third parties except as provided in this Privacy Policy.
Last updated 2020/05/21
Data Usage Policies and Disclaimers

The access to MGeND is subject to the terms and conditions described below. Your use of MGeND constitutes your agreement to these terms and conditions.

  1. Eligibility for Data Use
    1. Anyone can use unrestricted-access data.
  2. Rights of Data Users
    1. Data users can freely make the result of the study for which data from MGeND are used public, as long as the responsibilities of data users and the limitation added for each data set are fulfilled.
    2. Data users can freely acquire intellectual property rights based on the result of the study for which data from MGeND are used, as long as the responsibilities of data users and the limitation added for each data set are fulfilled.
  3. Responsibilities of Data Users
    1. In using data, the data user must utilize the data with his/her own responsibility and evaluation of the quality, content, and scientific validity of the data.
    2. The data user must comply with the following rules
      • Identification of individuals who are the original data donor is prohibited.
      • The latest data should be downloaded and used.
      • The use of data is limited for research purposes only in principle. For commercial use, please consult with us in advance.
    3. When the research results including data downloaded from MGeND are made public in a publication or a presentation, a statement such as the following** must be included as acknowledgment, and please consider citing our publications described on this page.
      ** Example of acknowledgement
      "(A part of) The data used for this research were originally collected and provided by the Medical Genomics Japan Variant Database (MGeND) (https://mgend.med.kyoto-u.ac.jp/) developed in the Program for an Integrated Database of Clinical and Genomic Information with funding from the Japan Agency for Medical Research and Development (AMED)."
    4. Please consult with us in advance when acquiring intellectual property rights using the data provided by MGeND.
  4. Cost of Data Use
    1. The data user bears costs incurred in connection with data use, if any.
  5. Disclaimers
    1. The contents on MGeND have been compiled with meticulous care, and we will make an effort to keep information up-to-date. However, we take no responsibility for the accuracy, completeness or up-to-dateness of any of this web site, and the information are subject to change without notice.
    2. The information on MGeND is not intended for direct diagnostic or medical decision-making.
    3. Users must comply with the (i) related laws, regulations, and guidelines, irrespective of the time of enactment, (ii) provisions for information management as established by MGeND, and (iii) other provisions relating to the handling of the Information.
    4. MGeND and submitters shall not be liable any trouble and damage occur to user or any third party through using the information on this web site.
  • Mayumi Kamada, Masahiko Nakatsui, Ryosuke Kojima, Sachio Nohara, Eiichiro Uchino, Shigeki Tanishima, Masaya Sugiyama, Kenjiro Kosaki, Katsushi Tokunaga, Masashi Mizokami, Yasushi Okuno (2019) “MGeND: an integrated database for Japanese clinical and genomic information”,
    Human Genome Variation, 6, 53 (2019). https://doi.org/10.1038/s41439-019-0084-4
Ethics Approval
MGeND is operated according to ethical approval from the Ethics Committee of Kyoto University Graduate School, Faculty of Medicine and Kyoto University Hospital.
Announcement of implementation of database research project (Japanese Only).
About Database and Data Registry,
Department of Biomedical Data Intelligence,
Graduate School of Medicine, Kyoto University
54 Shogoin-Kawaharacho, Sakyo-ku, Kyoto, Japan

MGeND Data Submission Committee
Email: info@mgend.med.kyoto-u.ac.jp
About Commercial Use and Intellectual Property;
Division of Biobank, Department of Research Infrastructure,
Japan Agency for Medical Research and Development
Program for an Integrated Database of Clinical and Genomic Information
Email: genome-db@amed.go.jp
Developed by
Kyoto University
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